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Amphetamine

Properties, data and information sources.

 

Contents

Amphetamine is an chiral organic chemical compound from the group of phenethylamine derivatives.

Important salts of amphetamine include: amphetamine hydrochloride, amphetamine phosphate and amphetamine sulfate.

 

Names and Identifiers

Name
Amphetamine
Formula
C9H13N
Molar mass
135.21 (g/mol)
CAS registry number
300-62-9
EC number EINECS
206-096-2
InChI Key
KWTSXDURSIMDCE-UHFFFAOYSA-N

Systematic name
1-Phenylpropan-2-amine

Other names, synonyms
1-Phenyl-2-aminopropane; α-Methylbenzeneethanamine; (±)-Desoxynorephedrine; (±)-α-Methylphenethylamine; (±)-β-Phenylisopropylamine; β-Aminopropylbenzene

Trade names; preparations
Actedron; Adipan; Allodene; Amphetamine; Anorexine; Benzedrine; Elastonon; Isoamyne; Isomyn; Mecodrin; Norephedrane; Amfetamin; Ortedrine; Phenedrine; Profamina; Propisamine; Raphetamine; Simpatedrin; Sympamine; Sympatedrine; Weckamine

 

Chemical formulas

Molecular formula and structural formula of Amphetamine:

 

C9H13N

Mr = 135.21 g/mol

1-Phenylpropan-2-amine
SMILES: CC(CC1=CC=CC=C1)N

 

Data and Properties

melting point
11.3 °C
boiling point
203 °C
density
0.93 g cm-3 at 20 °C
pKa value
pK1a = 10.13
vapor pressure
3 hPa at 20 °C
refractive index
nD = 1.518 at 26 °C

 

Spectroscopic data:

SPLASH (mass spectra)
splash10-014r-0900000000-8c26eef755113726e527
splash10-014i-0900000000-8cb9815fcd67a6b46f05
MoNA Mass Bank of North America (mass spectrum)
KWTSXDURSIMDCE-UHFFFAOYSA-N
SpectraBase (NMR, IR, FTIR, Raman, UV-Vis, MS ... spectra)
1ty8WReZV9M
NIST IR-Spektrum
Amphetamine
Human Metabolome Database (GC-MS, LC-MS/MS spectra, NMR)
HMDB0014328

Calculated NMR spectrum (Predict Spectra via NMRDB)
1H NMR Spektrum, 13C NMR Spektrum.

 

Percentage and isotopic composition:

Mass-related elemental composition and isotope proportions of the compound Amphetamine - C9H13N - calculated based on molecular mass.

Symbol
Element E
Number x
of atoms Ex
Data of the element
and isotopes *
Percentages
of isotopes
Percentage of
Ex in formula mass
C
Carbon
9 Ar = 12.011 u
ΣAr = 108.099 u
12C: 12 u [98,94 %]
14C: 14.00324 u [<< 1 %]
13C: 13.00335 u [1,06 %]
 
12C: 79.10151 %
14C: trace
13C: 0.84746 %
79.9490 %H
Hydrogen
13 Ar = 1.008 u
ΣAr = 13.104 u
3H: 3.01605 u [<< 1 %]
1H: 1.00783 u [99,99 %]
2H: 2.0141 u [0,01 %]
 
3H: trace
1H: 9.69062 %
2H: 0.00097 %
9.6916 %N
Nitrogen
1ΣAr = 14.007 u
14N: 14.00307 u [99,6205 %]
15N: 15.00011 u [0,3795 %]
 
14N: 10.32013 %
15N: 0.03931 %
10.3594 %

*) The third column lists the atomic masses or isotope masses of the elements involved and - in square brackets - the natural isotope composition.

 

More calculated data

The molar mass is M = 135.21 grams per mole.

The amount of substance in one kilogram of the substance is n = 7.396 mol.

The amount of substance in one gram of the substance is n = 0.007 mol.

Monoisotopic mass: 135.10479942285 Da - related to 12C91H1314N.

 

Amphetamine as Active Ingredient

ATC Code:
N06BA01
N06BA02
N06BA12

Amphetamine is a drug used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Known metabolites include: hydroxyamphetamine, 4-hydroxynorephedrine, 4-hydroxyphenylacetone, N-hydroxyamphetamine, benzoic acid, hippuric acid, norephedrine and phenylacetone.

For detailed information on the active ingredient, see: DrugBank DB00182, NCI Thesaurus C62006.

 

Hazard warnings according to GHS

(General information without guarantee of accuracy and completeness! The information does not replace the chemical safety data sheet or a risk assessment, but rather provides a general overview of the risk posed by the hazardous substance.

Signal word: Danger

GHS hazard statements (H phrases):


H226
Flammable liquid and vapour

H300
Fatal if swallowed

LD50 (mouse, oral): 21 mg/kg.


Labeling in the EU: See ECHA Substance Infocard 100.005.543.

For toxicology and occupational safety when handling Amphetamine as well as measures to be taken in case of danger, see: Hazardous Substances Information System GESTIS, ZVG-Nr. 490189.


Note: The labeling requirement according to the CLP Regulation (EU) does not apply, among other things, to certain substances and mixtures for end users that are in the form of finished products, such as pharmaceuticals, veterinary drugs, cosmetics, certain medical products and medical devices, food or feed, as well as certain Food additives or flavorings. Special legal regulations may need to be adhered to here.

 

External Sources

PubChem:ID 3007ChemSpider:ID 13852819Kegg database DBGET:ID D07445UNII of the FDA (USA):Unique Ingredient Identifier CK833KGX7EEPA CompTox Chemicals Dashboard:DTXSID4022600Other CAS RN:17108-96-2; 60-15-1; 96332-84-2 (also used, outdated or deleted registration numbers)

 

Manufacturers and Sources of Supply

The table below lists producers and suppliers of Amphetamine as a commercial chemical for laboratories, research, industry and production with the corresponding contact details.

 

Literature Sources

[0] - Specialist and research articles in scientific journals via PubMed: Amphetamine.

 


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Last update: 2026-02-11


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